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AOD-9604 Research Protocols & Administration Dosing in Published Research Research investigations have employed diverse AOD-9604 doses across species and administration routes: Rodent studies: 250-500 mcg/kg orally or intraperitoneally was most common for obesity research Rabbit models: 0.25 mg per joint for osteoarthritis studies (intra-articular injection) Pig pharmacokinetic studies: 1.5 mg/kg IV and 2 mg/kg oral for metabolism characterization Human clinical trials: Oral doses of 0.25-10 mg daily

Gastrointestinal tolerability often improves with slower titration schedules

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Morimoto, M., Hashimoto, T., Tsuda, Y., Nakatsu, T., Kitaoka, T., and Kyotani, S., PLoS One , 2020, vol

Sachdeva and Anurag Kuhad 2011)

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