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These alterations in the tumor ECM induce an increase in its stiffness, typically evaluated using techniques that either require direct contact with the sample (e.g., atomic force microscopy), or measure the tumor mechanical properties in a contact-free manner (e.g., shear wave elastography, magnetic resonance elastography) (Table 3)

A full abdominal examination must be performed, importantly to assess for peritonism, hepatomegaly, or stigmata of liver disease

This combination uses two distinct pathways to amplify GH release synergistically

The cumulative, sustained-release mechanism means gaps in dosing can reduce effectiveness

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