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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

126 The upregulation of IDH1 may represent a common metabolic adaptation for diminishing oxidative stress and supporting macromolecular synthesis, consequently promoting tumor growth and therapy resistance

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Tavilani H, Goodarzi MT, Doosti M, et al

The amylin pathway is distinct from both GLP-1 and GIP signaling

183 Indeed, holomycin induces broad spectrum zinc and iron starvation, with striking parallels to that of the antimicrobial protein, calprotectin, providing support for the idea that transition metal-starvation is an evolutionarily conserved weapon to keep microbial predators at bay

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