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A systematic review and meta-analysis published in the American Journal of Geriatric Psychiatry , which analyzed data from 2,071 participants , found that people receiving GLP-1 receptor agonists experienced modest but significant improvements in depression scores compared with placebo or other diabetes medicine s (4 The Antidepressant Effects of GLP-1 Receptor Agonists: A Systematic Review and Meta-Analysis Go to source) Trusted Source The Antidepressant Effects of GLP-1 Receptor Agonists: A Systematic Review and Meta-Analysis Go to source)

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HMB has some support in older adults and during severe deficits, but it does not replace creatine