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After treatment, brain tissues were harvested and evaluated for oxidative stress biomarkers (8-OHdG, MDA, GPx, GSH, GST, SOD), pro-inflammatory cytokines (MPO, NF-B, TNF-), ion transport enzymes (Na/K ATPase, Ca ATPase), neurotransmitter levels (dopamine, serotonin, AChE), and the apoptotic marker caspase-3

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In the definition of high priority measure, the phrase care coordination, opioid, or health equity-related quality measure. is removed and added in its place is the phrase care coordination or opioid-related quality measure.