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This integrated approach addresses root causes rather than managing individual symptoms

Environ Sci Pollut Res 14(7):490497 Schulte-Oehlmann U, Oehlmann J, Pttmann W (2007) Humanpharmakawirkstoffe in der Umwelt: Eintrge, Vorkommen und der Versuch einer Bestandsaufnahme

Biochimica et Biophysica Acta Mol Basis Dis

2006;2:CD000254

It phosphorylates upstream stimulatory factor 1 (USF1) and then upregulate fatty acid synthase (FASN), which promotes de novo lipogenesis (DNL) in liver and aggravates hepatic fat deposition

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