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Possible mechanisms involved in tumorigenesis in offspring derived from oxidatively damaged IVF embryos From the abovementioned 240 differentially expressed proteins, we enriched 58 tumor-related proteins, including 45 upregulated and 13 downregulated proteins, and analyzed tumor-related signaling pathways (Supplementary Tables 3 and 4)
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Concurrently, downregulation of STAMBP and NEP may impair protein clearance mechanisms, exacerbating proteotoxic stress and -amyloid (A) deposition [52], ultimately triggering neuronal apoptosis, which aligns with our previous observation of reduced MAP2-positive neurons
Matrix Metalloproteinase-9 as an important contributor to the pathophysiology of Depression
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