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Unlike full hGH, it focuses solely on lipolysis (fat breakdown) and lipogenesis inhibition (preventing fat formation) without significantly affecting blood sugar levels or increasing IGF-1

In separate Phase 2 and Phase 3 trials, retatrutide at 12mg produced greater total body weight reduction than semaglutide at 2.4mg across comparable timeframes, with the difference primarily attributable to retatrutides additional glucagon receptor activation

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doi:10.1016/S0736-0266(03)00110-4 Goldstein AL, Hannappel E, Sosne G, Kleinman HK