localized reaction to tirzepatide Injection Site Itch: Causes & Management – PlexusDx Tirzepatide Injection Site Itching: Causes

This effect is usually temporary but can persist for a few months

This increase was associated with a 1.5-fold increase in portal plasma GLP-1 upon gastric glucose stimulation in diet-induced obese VSG rats compared to diet-induced obese sham controls, suggesting that antral GLP-1 producing cells contribute significantly to portal GLP-1 (Ribeiro-Parenti et al., 2021)

doi: 10.1007/s10495-015-1150-0

Nausea is the most prevalent side effect, affecting approximately 16-20% of Ozempic patients and up to 44% of Wegovy patients in clinical trials

By binding to GLP-1 receptors in the brain, semaglutide stimulates insulin release and suppresses appetite, effectively managing blood sugar levels and supporting weight management

Diarrhea is another concern