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GLP-1 receptor agonists in the treatment of type 2 diabetes - state-of-the-art

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[DOI] [PubMed] [Google Scholar] Johri et al

Because it is a natural, biological extract, it contains a vast array of active neurotrophic factors, including BDNF (Brain-Derived Neurotrophic Factor), NGF, and remarkably high levels of GDNF-promoting elements

GLP-1 also incorporated a di-alanine (AA) leader that facilitated recombinant expression, but that is removed in vivo by dipeptidyl peptidase 4 (DPP4) to expose an active N terminus ( 24 )

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