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Mitchell KG, Ikoma N, Nelson DB, Maru DM, Erasmus JJ, Weston BR, Vaporciyan AA, Antonoff MB, Mehran RJ, Rice DC, Roth JA, Swisher SG , Sepesi B, Walsh GL, Correa AM, Das P, Blum MA, Badgwell BD, Hofstetter WL

Caspani, G., Turecki, G., Lam, R

Three critical warning signs that require immediate attention: Persistent gastrointestinal symptoms Vomiting or diarrhea lasting more than 48 hours, potentially leading to dangerous dehydration Severe abdominal pain Particularly in the upper abdomen, which may indicate pancreatitis, a serious complication Allergic reactions Including difficulty breathing, facial swelling, or widespread rash The distinction often lies in intensity and duration

Clinical trial data provides insight into comparative effectiveness across different populations and timeframes

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J Thorac Cardiovasc Surg 158(3):911-919, 2019