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Taleb SA, Ibrahim BMM, Mohammed MA, Yassen NN, Hessin AF, Gad SA, et al

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FIGURE 2 The primary ROS produced by the ETC is superoxide, a free radical with moderate reactivity, whose generation can lead to more reactive or secondary ROS derivatives

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However, acetaminophen inhibits both COX isoforms by acting on the peroxide site and reducing the amount of the PTGS oxidized form required for AA conversion [2,80,81]

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