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Materials and Methods Cell Culture The human retinal pigment epithelium cell line, ARPE-19 (ATCC, Manassas, USA), was cultured in Dulbeccos modified Eagles medium Nutrient Mixture F-12 (1:1 mixture of Dulbeccos modified Eagles medium and Hams F12

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Reduces Oxidative Stress Free radicals accelerate skin aging and pigmentation

Unlike antioxidants that scavenge reactive oxygen species after formation, SS-31 selectively binds to cardiolipin, a phospholipid essential for mitochondrial inner membrane structure and electron transport chain function