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Such a complex had negligible pro-inflammatory properties when compared with CFA, so a potential application of such an adjuvant would be conceivable in humans

National Center for Biotechnology Information, U.S

According to the NHS, its still unclear what causes sarcoidosis to develop in any one individual, but an initial trigger is likely to set off the sequence of events that lead to this specific type of immune system overactivity

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10.3390/diseases11010050 4 AldhaleeiW

A complementary axis involves transcriptional reinforcement of antioxidant programs, including NFE2 like BZIP transcription factor 2 (NFE2L2, also known as NRF2) signaling, which increases GPXs and further suppresses ROS-driven inflammasome activation 58