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Genes 15 , 1316 (2024)

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GHK-Cu can cause injection site reactions due to the copper peptides local irritation effect

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Glutathione can regenerate other antioxidants, such as vitamins C and E, enhancing their effectiveness in fighting oxidative stress

The potential irritation can be minimized by adjusting the pH of the nasal formulation to 4.56.5 to match the normal pH of the nasal mucosa (Vidyavathi et al., 2021)