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Glutathione exists in two primary states within the cell: Reduced glutathione (GSH): The active, antioxidant form Oxidized glutathione (GSSG): The spent form, converted back to GSH by the enzyme glutathione reductase using NADPH Under healthy physiological conditions, more than 98% of cellular glutathione exists in the reduced (active) form

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Thus, the less inhibitory effects of MOR blockade in the SNc relative to VTA could account for relative increases in DA release in the dorsal striatum during NPW

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