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The candidate agents extend current antibiotics classes with, for example, second-generation polymyxins (MRX-8 and upleganan, both in Phase I), an aminoglycoside (apramycin, Phase I), a tetracycline (zifanocycline, Phase I) and a macrolide (nafithromycin, Phase II) as well as new beta-lactam/beta-lactamase inhibitor (BL/BLI) combinations (ceftibuten/ledaborbactam, Phase I

Highly fermentable fibers like inulin and fructooligosaccharides can cause significantly more gas and bloating when transit time is already extended

doi: 10.3390/biomedicines9111547

However, it's always advisable to consult with a healthcare professional before starting any new supplement, especially if you have pre-existing health conditions or are taking other medications

GLP-1 agonists can be valuable for selected patients, particularly those with obesity and metabolic comorbidities, but long-term PCOS care should remain holistic combining metabolic management with mental health support, lifestyle sustainability, reproductive health, and patient education

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