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Microdose tirzepatide may be a good fit for patients who want a gentle dual-pathway option, are concerned about side effects, have previously experienced nausea on GLP-1 medications, or want gradual weight management support

The population of particular concern is individuals with atypical anorexia

Oct 2002;56(8):365-79

Adult obesity complications: challenges and clinical impact

This happens because medication does not address: Stress and emotional eating Poor sleep Low muscle mass Inadequate strength training For peri-menopausal women, repeated cycles of weight loss and regain can worsen bone loss and muscle decline , increasing long-term injury risk

Orforglipron is the real wildcard: a true small molecule, cheaper to make, eventually a clean tablet generic