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This happens because GLP-1 medications help suppress appetite and slow digestion while in use, but once stopped, the body returns to its pre-medication stateleading to a rapid return of hunger and a slower metabolism due to weight loss

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Consequently, this results in a reduction in the expression of PGC-1 (Pirooznia et al., 2020)

J Clin Endocrinol Metab 87: 489-499 Saravanan P, Chau WF, Roberts N, Vedhara K, Greenwood R, et al