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Permanent treatment discontinuations because of AEs were more common with liraglutide (12.6% [n = 16]) vs semaglutide (3.2% [n = 4]) and placebo (3.5% [n = 3])

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Use With Caution in Research Contexts Because Retatrutide interacts with GLP-1, GIP, and glucagon receptor pathways involved in metabolism, appetite regulation, gastric-emptying pathways, and glucose signaling, additional caution may be warranted in research models involving significant metabolic, gastrointestinal, pancreatic, or cardiometabolic conditions