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UMFA can accumulate when folic acid intake exceeds the bodys capacity to convert it into biologically active folate, particularly in individuals with reduced activity of the dihydrofolate reductase (DHFR) enzyme, which catalyses the first step in folic acid metabolism

Total monthly cost: scenario comparison The Bridge Program reduces monthly medication cost by roughly $1,000 compared to retail cash pay

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SGLT2 inhibitors (such as dapagliflozin or empagliflozin), which are used to treat type 2 diabetes, cause glucose to be excreted in the urine and can significantly increase urine output through osmotic diuresis