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In contrast, iTregs arise in the periphery, where cytokines such as TGF- and IL-2 promote their antigen-induced Foxp3 expression and suppressive function, thereby establishing tolerance to foreign antigens

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These doses provide meaningful metabolic benefits including improved insulin sensitivity and enhanced fat oxidation without the profound appetite suppression that makes eating adequate calories difficult

Some people experience constipation, mild bloating, or changes in bowel habits

Three randomized clinical trials, namely SURPASS-3, SURPASS-4, and SURPASS-AP-Combo, with 4339 patients were included