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Preclinical studies suggest that GLP-1RAs have a beneficial effect on major NAFLD histological outcomes, i.e., hepatic steatosis and inflammation, through multiple intrahepatic mechanisms, including increased fatty acid -oxidation, activation of autophagy, suppression of inflammation, and oxidative stress

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People often refer to them as GLP-1s or GLPs

Renal disease and hypertension in non-insulin-dependent diabetes mellitus

In these STEP trials, most participants experienced mild to moderate symptoms, with the incidence of severe side effects being 9.8% in the semaglutide treatment group and 6.4% in the placebo group

We also confirmed that the association of rs10305420 with GLP1 medication efficacy cannot be accounted for by T2D or smoking status (Supplementary Information and Supplementary Tables 7 and 8)