CDC.gov states: Aspiration before injection of vaccines or toxoids (i.e., pulling back on the syringe plunger after needle insertion but before injection) is not necessary because no large blood vessels are present at the recommended injection sites, and a process that includes aspiration might be more painful for infants (ACIP Vaccine Administration Guidelines for Immunization | Recommendations | CDC, 2018)
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This is much more common in people who take hydralazine for an extended period of time, which would not be the case for how hydralazine is currently clinically used (for acute situations on a short-term basis)
It's a hard-and-fast rule that should never be bent if you're serious about your work
That matters because blood-sugar control does the opposite: HbA1c is nearly maxed out by 10 mg, so the top dose is justified by weight, not by additional glucose lowering. Body size also shifts the felt dose
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