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Insulin and insulin secretagogues - Adding tirzepatide to insulin or insulin secretagogues (e.g., sulfonylureas, meglitinides) increases the risk of hypoglycemia

This differential receptor engagement profile distinguishes it structurally and pharmacologically from both single-agonist GLP-1R compounds and dual GLP-1R/GIPR agonists currently under investigation

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The liver is the main site of lipid metabolism and lipid metabolism disorders caused by obesity are a major cause of non-alcoholic fatty liver disease