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In addition, fatty acids have been proposed to play a role in pain modulation and even fatty acid depletion in some neuropathies

Bydureon may be prescribed as a triple therapy regimen in combination with the following: Metformin and a sulphonylurea Metformin and a thiazolidinedione Alternatively, Bydureon may be prescribed as a dual therapy with either metformin or a sulphonylurea

Additionally, inhibiting both FFA1 and GPR119 at the same time does not impact GLP-1 secretion upon chylomicron treatment in primary duodenal cultures (Psichas et al., 2017)