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In this context, elegant studies published by Ira Tabass group have contributed to the understanding of cellular metabolism by demonstrating that macrophages use amino acids, such as arginine and ornithine, derived from the degradation of ACs to synthesize putrescine that activates Rac1, which stabilizes the machinery required for actin remodeling and plasma membrane projection, supporting continuous efferocytosis

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When combined, the two create a synergistic Wolverine effect, where BPC157 tends to provide more local healing while TB500 offers systemic recovery support across multiple tissue types