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The human body produces it endogenously, with plasma concentrations averaging roughly 200 ng/mL at age 20 and declining to approximately 80 ng/mL by age 60 [1]

Participants were assigned in a 3:1 ratio to receive once-weekly CagriSema (2.4 mg each of cagrilintide and semaglutide) or placebo for 68 weeks, alongside standardised lifestyle interventions

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Luque Contreras D, Vargas Robles H, Romo E, Rios A, Escalante B

FIG 34 Phase I metabolism of Dihexa