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ISRN Pharmacol 2013;2013:147238

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They also suggested that factors that alter the function of the blood-brain barrier (BBB), such as hypoxic or ischemic stroke, inflammation that causes endothelial upregulation of surface adhesion molecules, and disruption of the BBB barrier function by the cancer, may alter the penetration conditions and reduce the permeability of the drug through the BBB [24]

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