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Attempts to increase exposure to UA have been made previously in the context of ischaemic stroke, one study finding that fewer patients underwent early ischaemic worsening after intravenous UA administration 54

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The sensitivity to GI side effects of GLP1s may be more pronounced in women because they already have a longer gut transit time compared to men, says Beverly Tchang, MD , Obesity Medicine Advisor for Ro and assistant professor of Clinical Medicine at Weill Cornell Medicine in New York