Tirzepatide promotes cAMP generation while minimally recruiting -arrestin, which reduces receptor internalization and extends surface signaling duration 35
It is important to note that this is not a cure for dementia
Rather quietly this week, Eli Lilly and Company announced that it had withdrawn an application to FDA for an indication to use tirzepatide (Zepbound) in treating heart failure specifically for HFpEF
About the GLP-1 RAs effects, it has been described that Exendin-4 attenuates NF-B p65 expression in the EAE spinal cord and blocks IB degradation in LPS-stimulated primary microglia, additionally demonstrating that exendin-4 can stop microglial polarization (Lee et al., 2018
The promise of superior metabolic benefits was too compelling
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