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534,535 Combination therapy, starting with a single agent and titrating to the maximum tolerated dose, may enhance efficacy when pain control is inadequate, with recent studies suggesting superior pain relief compared to monotherapy

Additionally, the evaluation of TAS, TOS, OSI, and PON-1 revealed a statistically significant increase in antioxidant activity in the liver, lung, and kidney tissues of the I/RB group

FASEB J 22(7):23932404 Logrip ML, Janak PH, Ron D (2009) Escalating ethanol intake is associated with altered corticostriatal BDNF expression