Patients should contact their GP or diabetes specialist nurse urgently if they experience: Widespread or severe itching that affects multiple areas of the body or significantly impacts quality of life and sleep Accompanying rash, hives (urticaria), or skin changes such as blistering, peeling, or discolouration Swelling of the face, lips, tongue, or throat , which may indicate angioedema Difficulty breathing, wheezing, or chest tightness , suggesting a potential anaphylactic reaction Persistent itching at injection sites that does not resolve within a few days or worsens over time Signs of infection at injection sites, including increased warmth, pus, or spreading redness Itching with yellowing of the skin or eyes (jaundice) , dark urine, pale stools, or right upper abdominal pain, which could indicate gallbladder or liver problems Anaphylaxis is a rare but serious hypersensitivity reaction that requires immediate emergency care
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Evaluation of treatment efficacy should not rely solely on weight reduction but also on endpoints such as fat mass (FM) and lean body mass (LBM)
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Glycemic Control and Cardiovascular Health: Improved glycemic control is crucial for individuals with diabetes to reduce the risk of cardiovascular complications
doi:10.1016/S0140-6736(18)32260-8 32
