Truncal adiposity, relative growth hormone deficiency, and cardiovascular risk
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Moreover, the complement systems activation in response to hyperuricemia has been implicated in the pathogenesis of various inflammatory conditions, including gout, renal injury, and type 2 diabetes (T2DM)
However, the molecular targets of BH4-mediated direct antioxidant effect remain undefined, and specific research in the hyperglycemic and hypoxic pathological microenvironment of DR is lacking, with the heterogeneous role of BH4 in retinal cells yet to be further elucidated
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