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[34] #8 - HEART HEALTH Oxidative damage to the heart often leads to heart disease like stroke, heart attacks, and other life-threatening conditions

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In leptin-resistant-obese mice, CR (1 month) reduced the levels of malondialdehyde (MDA) in the serum and increased the level of peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 protein), which is a member of a family of transcription coactivators with a central role in the regulation of energy metabolism) (Waldman et al., )

Metformin use and risk of B12 deficiency increases with the dose and the duration depletion can be seen as early as 3-4 months after starting so it is important to attend for follow up blood tests and talk to your doctor

We further demonstrate that the BH3-only proteins Bim and Bid have an essential role in the synergistic LSEC death induced by paracetamol and TRAIL

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