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Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis

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This binds highly to albumin in the plasma, and prolongs half-life

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It is most helpful for: Patients with significant appetite return after GLP-1 discontinuation Those needing a 13 month bridge while transitioning to another long-term therapy (e.g., Contrave) Individuals who previously responded well to it and tolerate stimulants Used strategically, it can help preserve momentum during treatment transitions