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Due to the existing overlap of the involved signaling pathways and disease patterns, it is also possible that not only the initial manifestation influences the development and pathology of a further chronic inflammation, i.e., along the gut-liver, gut-joint, and gut-brain axes, but also that the therapeutic modulation of one disease has an impact on other organ systems [82]

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doi: 10.1186/s12967-020-02455-0 9 JasonLARichmanJARademakerAWJordanKMPlioplysAVTaylorRRet al