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GLP-1's Half-Life and Dosing Timeline Long-acting GLP-1 receptor agonists such as semaglutide have an elimination half-life of about 7 days, which allows for once-weekly dosing

doi: 10.2337/ds17-0011 Glugliano D et al (2021): GLP-1 receptor agonists vs

In the SELECT trial, which included more than 17,000 patients with obesity and cardiovascular disease but not diabetes, semaglutide cut the rate of major cardiac events by 20%

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Child (birth-17) was used as an eligibility criterion to select only the trials conducted with children