does semaglutide affect serotonin GLP-1 receptor agonists may dampen libido, likely through brain pathways tied to appetite and reward, though mechanisms remain unclear. Emerging data suggest receptor effects may play a role, but clinicians note Semaglutide and Depression | Eternity

SCFAs inhibit the NFB pathway and reduce the production of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-, which can alleviate skin symptoms in psoriasis, acne, or HS (169)

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References: Tomas M, et al

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We found that both the discovery cohort and the validation cohort showed a remarkable negative association between GLP-1R gene expression and the risk of DR in the primary analysis using the MR method, and these results were in agreement with the Meta-analysis results