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Adaptability for Special Populations The "Ultimate Solution" for Extreme Obesity (BMI 50) Traditional weight-loss medications show limited efficacy for morbidly obese patients (BMI 40), while gastric bypass surgery achieves 30%-35% weight reduction but carries surgical risks (e.g., anastomotic leaks, malnutrition) and long-term complications (e.g., dumping syndrome)

7 This is because GLP-1 receptor agonists reduce food intake by regulating appetite and hunger and promoting fullness and satiety

doi: 10.1001/jama.1982.03320260047031 84 Padilla-SalinasRSunLAndersonRYangXZhangSChenZJet al

Patient 3 This 65-year-old mom decided to take control of her life

2020 Mar 9;21(5):1856

Lyon: IARC (2018)