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Similar in vitro work showed that HGF promoted dendritic arborization in hippocampal neurons, an effect that could be blocked by NMDA receptor antagonists and was dependent on intracellular calcium and CaMKII activity [2]

Retatrutides triple-agonist approach represents one direction, while quadruple-agonists and amylin-combination peptides like CagriSema are advancing through clinical trials for 2026 and beyond

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