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Clinical Scenarios: When to Use or DePrioritize Metformin Scenario 1: Newly Diagnosed, Low Cardiovascular Risk A 48-year-old patient with newly diagnosed type 2 diabetes, an A1C of 7.3%, and no cardiovascular risk factors may still benefit from starting metformin

GLP-1s, or glucagon-like peptide-1 receptor agonists, regulate blood sugar levels by increasing insulin release and slowing digestion

For example, one study found that patients with RA who took semaglutide actually had better joint health over time

in most studies, these mechanisms are not distinguished

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