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A significant amount of work had previously shown that the molecules encoded by the neuroligin genes localize to synapses and aid in their development and maturation (Scheiffele et al., 2000)

While leflunomide has been shown to be effective in treating RA, its use is accompanied by certain limitations and potential adverse effects, including diarrhea, nausea, alopecia, and hepatotoxicity, as reported in previous studies (205, 206)

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