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doi: 10.1126/science.1241214

[PMID: 18534556 DOI: 10.1016/j.biopsych.2008.04.022] [DOI] [PubMed] [Google Scholar] 71.Berk M, Copolov D, Dean O, Lu K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Judd F, Katz F, Katz P, Ording-Jespersen S, Little J, Conus P, Cuenod M, Do KQ, Bush AI

An important role of GSSG in the NFkB activating signal cascade is suggested by the fact that the potent NFkB inducer TPA increases intracellular GSSG levels and GSSG/GSH ratios

Despite growing evidence supporting the beneficial effects of food-derived molecules on the maintenance and restoration of intestinal barrier integrity, several key challenges remain

According to the findings related to the three aforementioned metabolic pathways, in addition to those showing iron accumulation, lipid peroxidation, and redox stress, it is not difficult to infer that ferroptosis plays a vital role in the pathogenesis and progression of IgAN