This table is a reference starting point
The second is tolerability, since gastrointestinal effects and discontinuation rates differ across candidates and are becoming a real point of differentiation, as set out in the full side-effect profile of the GLP-1 class
Studies in obese rodents fed high-fat diets for extended periods show that diminished carnitine reserves in skeletal muscle are accompanied by marked perturbations in mitochondrial fuel metabolism, including reduced complete fatty acid oxidation, elevated incomplete -oxidation, and impaired substrate switching from fatty acid to pyruvate oxidation
Options include higher dosing to finish faster, freezing portions (accepting some potency loss), or accepting the waste as acceptable cost of the protocol
It's vegan-friendly, allergen-free, and GMO-free perfectly aligned with clean label trends
CT-388 also displayed good tolerability with mild GI-related side effects consistent with other GLP-1 therapies