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The authors further explored the expression of genes related to reproductive hormone receptors, leptin signaling molecular biomarkers, pro-inflammatory cytokines, OS and cell cycle mediators in the testis (133)
This creates constant energy demand, leading to a massive influx of oxygen and the production of reactive oxygen species (ROS) that can damage the very cellular machinery that powers the cell
Chemotherapy with drugs like 5-fluorouracil has also been associated with acute thiamine deficiency by disrupting thiamine activation, so oncology patients receiving such therapy might receive parenteral thiamine supplementation as part of this B-Complex if needed
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