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Despite the importance of DNL, aberrant upregulation is associated with a wide variety of pathologies

doi: 10.1590/0001-3765201520140671 183 Molnar-KaszaA.HintereggerB.NeddensJ.RablR.FlunkertS.Hutter-PaierB

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Many disorders such as spinocerebellar ataxia type 18, intellectual disability, speech impairment, etc., are associated with the impaired GluR2 receptor in the cerebellum of human patients [209, 249, 250]

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