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Biologic agents are usually injected either subcutaneously (under the skin) or intravenously (through a tube inserted into a vein)

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Some participants taking the higher doses had peak heart rate increases at the 24-week mark, but these rates declined as the study progressed

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Physiol Behav 107:34-39, 2012

However, severe gastrointestinal symptoms or chronic laxative use might affect nutrient absorption and hydration, which could indirectly influence how well semaglutide works