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Both adenosylcobalamin and hydroxycobalamin are generally considered highly safe and well-tolerated, as they are water-soluble vitamins and excess amounts are easily excreted in the urine

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Miura T, Noma H, Furukawa TA, Mitsuyasu H, Tanaka S, Stockton S, et al

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Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimers disease