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J Invest Dermatol (2004) 123:2333

HCRU was assessed over the baseline and follow-up periods (including index date) and expressed as both the proportion of patients with utilization, and as per-patient number of visits averaged across both cohorts

Patients with Hashimoto's thyroiditis show significantly decreased glutathione levels compared to healthy controls

This gap is why clinical protocols for acute glutathione repletion -- liver support, immune challenges, detoxification -- consistently use parenteral routes rather than oral supplementation

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